Ryan Reyes, a fourth-year graduate student (6th year MSTP student) in the lab of Tyler Curiel, M.D. MPH, just had two first author papers accepted in excellent journals on the same day.
The Curiel lab studies cancer immunotherapy and has expertise in using mouse models for translational research. Ryan’s project focuses on the use of novel approaches to target cancer fighting immune cells in the tumor microenvironment of bladder cancer. He is in the South Texas Medical Scientist Training Program specifically in the Molecular Immunology & Microbiology discipline.
Upon completion of his Ph.D., he will return to medical school and then pursue a residency/fellowship in Internal Medicine/Hematology & Oncology.
“These publications were only possible because of the excellent efforts of everyone in the Curiel and Svatek lab groups,” Reyes said.
The Journal for the Immunotherapy of Cancer (highest impact cancer immunotherapy journal in the world), in press:
CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation
Ryan M Reyes, Yilun Deng, Deyi Zhang, Niannian Ji, Neelam Mukherjee, Karen Wheeler, Harshita B Gupta, Alvaro S Padron, Aravind Kancharla, Chenghao Zhang, Myrna G Garcia, Anand VR Kornepati, Onur Boyman, José R. Conejo-Garcia, Robert S Svatek, Tyler J Curiel
Cancer Medicine, in press:
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy
Deyi Zhang§, Ryan M Reyes§, Erica Osta, Suresh Kari, Harshita B Gupta, Alvaro S Padron, Anand VR Kornepati, Aravind Kancharla, Xiujie Sun, Yilun Deng, Bogang Wu, Ratna Vadlamudi, Rong Li, Robert S Svatek, Tyler J Curiel