Dr. Patrick Sung is the principal investigator of a $3.75 million, four-year “team science” grant announced by the Gray Foundation of New York. The goal is to further study how inactivation of BRCA1 or BRCA2, along with other anomalies, leads to breast, ovarian and other cancers.

“BRCA1 and BRCA2 promote tumor suppression,” said Dr. Sung, holder of the Robert A. Welch Distinguished Chair in Biochemistry at UT Health San Antonio. “These genes help orchestrate the removal of potentially harmful lesions from DNA. As such, BRCA mutations compromise the integrity of our genetic blueprint, resulting in malignant transformation of cells in the breast and ovary to cause cancer.”

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